NESA Biology Genetic Variation
15 sample questions with marking guides and sample answers · Avg. score: 70.9%
Sheep have 54 chromosomes, while goats have 60 chromosomes. The hybrid offspring of a sheep-goat pairing is called a geep.
During fertilisation, an egg from the sheep is fertilised by a sperm from the goat, resulting in a geep.
Which of the following will be correct for the geep?
chromosomes
chromosomes
chromosomes
chromosomes
Reveal Answer
chromosomes
Incorrect. The geep receives 27 chromosomes from the sheep and 30 from the goat, making its total chromosome count 57, not a haploid number of 29.
chromosomes
Incorrect. The total chromosome count is determined by adding the haploid numbers of the parents (), not 52.
chromosomes
Correct. The sheep egg provides a haploid set of 27 chromosomes () and the goat sperm provides 30 chromosomes (), resulting in a diploid geep with chromosomes.
chromosomes
Incorrect. This is the sum of the parents' diploid numbers (). Fertilization involves the fusion of haploid gametes, not diploid cells.
Which mode of inheritance leads to continuous variation in the phenotypes of a population due to the cumulative effect of multiple genes?
codominance
polygenic inheritance
incomplete dominance
multiple allele inheritance
Reveal Answer
codominance
Codominance occurs when both alleles of a single gene are fully expressed in the heterozygote (e.g., AB blood type), resulting in discrete phenotypes rather than continuous variation.
polygenic inheritance
Polygenic inheritance involves multiple genes contributing additively to a single trait, creating a continuous spectrum of phenotypes (such as height or skin color) across a population.
incomplete dominance
Incomplete dominance describes a single-gene interaction where the heterozygote is intermediate between homozygotes, but it does not produce the broad continuous variation caused by multiple genes.
multiple allele inheritance
Multiple allele inheritance refers to the presence of more than two alleles for a single gene within a population (e.g., ABO blood groups), which typically results in distinct categories rather than continuous variation.
A computer simulation was used to observe genotypic changes in the gene pool of 20 randomly selected rabbits. The simulation was set with these parameters:
- each rabbit's coat colour was either black or white
- black alleles were dominant; white alleles were recessive
- the number of rabbits was constant in each generation and breeding was random throughout the population
- an environmental factor was chosen in the simulation to provide selection pressure.
The table shows the results of the simulation at the start and after 20 generations.
| Initial population genotypes | Population genotypes after 20 generations |
|---|---|
| BB BB BB BB BB BB | BB BB |
| Bb Bb Bb Bb Bb Bb Bb Bb Bb Bb | Bb Bb Bb Bb Bb Bb Bb Bb |
| bb bb bb bb | bb bb bb bb bb bb bb bb bb bb |
Contrast the initial allele frequency with the allele frequency after 20 generations to draw a conclusion about the effect of the selection pressure on the rabbit population.
Reveal Answer
Initial allelic frequencies were B 0.55 and b 0.45.
Allelic frequencies after 20 generations were B 0.3 and b 0.7.
B decreased (from 0.55 to 0.3) and b increased (from 0.45 to 0.7).
This selection pressure was in favour of white rabbits as both genotype and allelic frequencies shifted toward the white phenotype and the white allele.
| Descriptor | Marks |
|---|---|
Provides the correct initial and final allele frequencies | 1 |
Identifies consequentially correct change in allele frequency | 1 |
States a consequentially valid conclusion | 1 |
Crossing-over is the exchange of
genes between homologous chromosomes.
genes between autosomal chromosomes.
alleles between homologous chromosomes.
alleles between autosomal chromosomes.
Reveal Answer
genes between homologous chromosomes.
Homologous chromosomes already contain the same genes in the same locations. Crossing-over exchanges different versions of those genes, not the genes themselves.
genes between autosomal chromosomes.
Crossing-over occurs specifically between homologous pairs, not random autosomal chromosomes, and it involves the exchange of alleles rather than genes.
alleles between homologous chromosomes.
Crossing-over is the process during meiosis where non-sister chromatids of homologous chromosomes exchange alleles, creating new combinations of genetic information and increasing genetic diversity.
alleles between autosomal chromosomes.
While crossing-over can occur on autosomal chromosomes, it specifically requires homologous chromosome pairs. Furthermore, crossing-over also occurs between homologous regions of sex chromosomes.
Alpha and Beta Thalassemia have similarities and differences in their inheritance patterns. Which of the following is correct?
Both are autosomal dominant conditions controlled on multiple gene loci.
Alpha Thalassemia is fatal for homozygote individuals while Beta Thalassemia is not.
Both are autosomal recessive conditions that result in affected individuals having four defective globin genes.
Beta Thalassemia is fatal for heterozygote individuals while Alpha Thalassemia is not.
Reveal Answer
Both are autosomal dominant conditions controlled on multiple gene loci.
This is incorrect because both Alpha and Beta Thalassemia are inherited as autosomal recessive conditions, not autosomal dominant.
Alpha Thalassemia is fatal for homozygote individuals while Beta Thalassemia is not.
This is correct. Homozygous Alpha Thalassemia (loss of all four alpha genes) causes hydrops fetalis, which is typically fatal in utero. Homozygous Beta Thalassemia is not fatal in utero because fetal hemoglobin relies on gamma chains rather than beta chains.
Both are autosomal recessive conditions that result in affected individuals having four defective globin genes.
This is incorrect because while Alpha Thalassemia involves four genes (two loci on chromosome 16), Beta Thalassemia involves only two genes (one locus on chromosome 11).
Beta Thalassemia is fatal for heterozygote individuals while Alpha Thalassemia is not.
This is incorrect. Heterozygotes for Beta Thalassemia (Beta Thalassemia Minor) are typically asymptomatic or experience only mild anemia, making it non-fatal.
Allele frequencies were monitored in two large populations of field mice from neighbouring forests over a 10-year period. Results are shown.
Forest X
| Year | Genotype AA | Genotype Aa | Genotype aa | Allele frequency A | Allele frequency a |
|---|---|---|---|---|---|
| 2013 | 52 | 146 | 102 | 0.42 | 0.58 |
| 2014 | 48 | 144 | 108 | 0.40 | 0.60 |
| 2015 | 55 | 147 | 98 | 0.43 | 0.57 |
| 2016 | 60 | 150 | 90 | 0.45 | 0.55 |
| 2017 | 58 | 142 | 100 | 0.43 | 0.57 |
| 2018 | 58 | 148 | 94 | 0.44 | 0.56 |
| 2019 | 59 | 152 | 89 | 0.45 | 0.55 |
| 2020 | 60 | 148 | 92 | 0.45 | 0.55 |
| 2021 | 65 | 149 | 86 | 0.46 | 0.54 |
| 2022 | 66 | 149 | 85 | 0.47 | 0.53 |
Forest Y
| Year | Genotype AA | Genotype Aa | Genotype aa | Allele frequency A | Allele frequency a |
|---|---|---|---|---|---|
| 2013 | 0 | 0 | 300 | 0.00 | 1.00 |
| 2014 | 0 | 0 | 300 | 0.00 | 1.00 |
| 2015 | 0 | 0 | 300 | 0.00 | 1.00 |
| 2016 | 0 | 15 | 285 | 0.03 | 0.98 |
| 2017 | 3 | 46 | 251 | 0.09 | 0.91 |
| 2018 | 14 | 60 | 226 | ||
| 2019 | 31 | 91 | 178 | 0.26 | 0.75 |
| 2020 | 48 | 104 | 148 | 0.33 | 0.67 |
| 2021 | 60 | 122 | 118 | 0.40 | 0.60 |
| 2022 | 66 | 137 | 97 | 0.45 | 0.55 |
Calculate the allele frequencies for forest Y in 2018. Show your working.
Reveal Answer
Frequency (a) =
Frequency (A) =
| Descriptor | Marks |
|---|---|
Provides appropriate working | 1 |
Calculates the frequencies of both alleles | 1 |
Identify temporal trends in allele frequency for forests X and Y and infer reasons for the observed differences.
Reveal Answer
Allele frequencies remained relatively constant in forest X over the 10-year period, with a slight increase in allele A over time. This suggests genetic drift is occurring and the changes are likely due to chance rather than the environment favouring a particular phenotype.
This contrasts with forest Y, where the frequency of allele A increases significantly over time after it first appears in 2016. The allele may have been introduced to forest Y due to migration (mice moving in from a neighbouring forest) or mutation. Either way, it is evident that the allele A provided a selective advantage to mice in forest Y, resulting in its frequency increasing over time.
| Descriptor | Marks |
|---|---|
Identifies allele frequencies remain relatively constant in forest X over time | 1 |
Infers a reason for the temporal change in forest X | 1 |
Identifies allele A first appeared in forest Y in 2016 | 1 |
Infers this is due to migration (gene flow) or mutation | 1 |
Identifies the frequency of allele A increases over time in forest Y | 1 |
Infers allele A provides a selective advantage to mice in forest Y | 1 |
A type of pea plant can have red or purple flowers. The table below shows the flower colour of parental plants and their offspring for five different crosses. Use this information to answer the question.
| Cross | Male Parent | Female Parent | Offspring |
|---|---|---|---|
| 1 | red | red | all red |
| 2 | red | purple | all purple |
| 3 | purple | red | all purple |
| 4 | purple | red | some with red and some with purple |
| 5 | ? | purple | some with red and some with purple |
What type of trait is red flower colour in the pea plants?
autosomal dominant
sex-linked dominant
autosomal recessive
sex-linked recessive
Reveal Answer
autosomal dominant
Crosses 2 and 3 show that when red and purple plants are crossed, all offspring are purple. This indicates that purple is the dominant trait and red is recessive.
sex-linked dominant
Red is a recessive trait, not dominant. Additionally, reciprocal crosses (Crosses 2 and 3) yield the same results, which indicates the trait is autosomal rather than sex-linked.
autosomal recessive
Red is recessive because crossing red and purple plants yields all purple offspring (Crosses 2 and 3). It is autosomal because reciprocal crosses produce the same results, ruling out sex-linkage.
sex-linked recessive
If the trait were sex-linked recessive, Cross 3 (purple male crossed with red female) would produce red male offspring. Since all offspring are purple, the trait must be autosomal.
In onion plants, bulb shape is controlled by the alleles at a single gene and can be round or elongated. Leaf colour is controlled by alleles at a different gene and can be purple or green. An onion plant with round bulbs and purple leaves is crossed with a plant with elongated bulbs and green leaves. The offspring all had round bulbs and purple leaves. This indicates that in onion plants,
purple leaves and round bulbs are dominant traits.
purple leaves and round bulbs are co-dominant traits.
leaf colour and bulb shape are environmentally determined traits.
leaf colour and bulb shape are polygenic traits.
Reveal Answer
purple leaves and round bulbs are dominant traits.
When two individuals with contrasting traits are crossed and all offspring express only one of the traits, the expressed traits (round bulbs and purple leaves) are dominant over the hidden ones.
purple leaves and round bulbs are co-dominant traits.
Co-dominance would result in offspring expressing both parental phenotypes simultaneously (e.g., leaves with both purple and green patches), rather than just one uniform phenotype.
leaf colour and bulb shape are environmentally determined traits.
The question explicitly states that both traits are controlled by alleles at specific genes, meaning they are genetically determined, not environmentally determined.
leaf colour and bulb shape are polygenic traits.
The question specifies that each trait is controlled by alleles at a "single gene," whereas polygenic traits are controlled by the interaction of multiple genes.
Random assortment of chromosomes occurs during
fertilisation.
meiosis I.
meiosis II.
mitosis.
Reveal Answer
fertilisation.
Incorrect. Fertilisation involves the random fusion of two haploid gametes to form a diploid zygote, rather than the random assortment of chromosomes during cell division.
meiosis I.
Correct. Random (independent) assortment occurs during metaphase I of meiosis I, when homologous chromosome pairs align randomly at the cell equator before separating into daughter cells.
meiosis II.
Incorrect. Meiosis II involves the separation of sister chromatids, not the random assortment of homologous chromosome pairs, which already took place during meiosis I.
mitosis.
Incorrect. Mitosis produces genetically identical daughter cells and does not involve the pairing or random assortment of homologous chromosomes.
Random assortment of chromosomes occurs in
binary fission.
fertilisation.
mitosis.
meiosis.
Reveal Answer
binary fission.
Binary fission is a form of asexual reproduction primarily used by prokaryotes to produce genetically identical offspring, so random assortment does not occur.
fertilisation.
Fertilisation is the fusion of gametes to form a zygote. While it randomly combines genetic material from two parents, the actual random assortment of chromosomes happens earlier during gamete formation.
mitosis.
Mitosis is a process of cell division that produces genetically identical daughter cells, meaning chromosomes do not randomly assort to create genetic variation.
meiosis.
Random assortment (or independent assortment) of homologous chromosomes occurs during metaphase I of meiosis, which is a key mechanism for generating genetic variation in gametes.
In rabbits, fur length is determined by the alleles at the 'L' gene, where the allele for long fur is dominant to the allele for short fur. A female rabbit with long fur mated with an unknown male rabbit and produced a litter containing some baby rabbits with long fur and some with short fur. Therefore, the
female rabbit must be a heterozygote at the 'L' gene.
female rabbit must have mated with more than one male.
unknown male rabbit must have had short fur.
unknown male rabbit must be a homozygote at the 'L' gene.
Reveal Answer
female rabbit must be a heterozygote at the 'L' gene.
Because the female rabbit has the dominant long fur trait but produces offspring with the recessive short fur trait (), she must carry one recessive allele, making her heterozygous ().
female rabbit must have mated with more than one male.
A single male rabbit carrying the recessive allele (either or ) is sufficient to produce a mixed litter of long and short-furred offspring when mated with a heterozygous female.
unknown male rabbit must have had short fur.
The male rabbit could have had long fur if he was heterozygous (), as he would still be able to pass on the recessive allele needed for short-furred offspring.
unknown male rabbit must be a homozygote at the 'L' gene.
The male rabbit could be either homozygous recessive () or heterozygous (); he just needs to carry at least one recessive allele to produce short-furred offspring.
Which form of inheritance usually determines traits that display continuous phenotypic variation?
polygenic
sex-linked
multiple allele
incomplete dominance
Reveal Answer
polygenic
Polygenic inheritance involves the additive effect of two or more genes on a single phenotypic character, resulting in a continuous range of variation (e.g., human height or skin color).
sex-linked
Sex-linked inheritance refers to genes located on the sex chromosomes (X or Y) and affects inheritance patterns based on biological sex, rather than causing continuous phenotypic variation.
multiple allele
Multiple allele inheritance involves a single gene having more than two alleles in the population (like ABO blood types), which typically results in distinct, discontinuous categories.
incomplete dominance
Incomplete dominance occurs when the heterozygote phenotype is an intermediate blend of the homozygotes, but it generally produces discrete phenotypes rather than a continuous spectrum.
Two alleles, and , are present for the agouti gene in mice. Mice that are homozygous for the allele have black fur, mice that have both the and alleles (i.e. heterozygotes) have yellow fur, and mice that are homozygous for the allele die before being born. Two yellow mice were mated repeatedly to produce multiple litters. Use this information to answer the question.
The proportion of surviving offspring that have yellow fur is expected to be
0.25.
0.33.
0.50.
0.67.
Reveal Answer
0.25.
Incorrect. The value 0.25 represents the proportion of offspring that inherit two copies of the lethal yellow allele and die before birth, not the proportion of surviving yellow offspring.
0.33.
Incorrect. The value 0.33 (or 1/3) is the expected proportion of surviving offspring that have non-yellow fur, rather than yellow fur.
0.50.
Incorrect. A proportion of 0.50 would be expected from a cross between a heterozygous yellow individual and a homozygous non-yellow individual, not a cross between two heterozygotes.
0.67.
Correct. The yellow fur allele is typically a recessive lethal allele. In a cross between two heterozygous yellow individuals, the homozygous yellow offspring do not survive, leaving a 2:1 ratio of yellow to non-yellow survivors, which is 2/3 or approximately 0.67.
Muscular dystrophy in golden retriever dogs is caused by a mutation of the dystrophin gene. It is much more common in male golden retrievers than females. On this basis, what type of condition is muscular dystrophy in golden retrievers?
sex-linked dominant
sex-linked recessive
autosomal dominant
autosomal recessive
Reveal Answer
sex-linked dominant
If the condition were sex-linked dominant, females would be more likely to inherit the condition than males because they have two X chromosomes.
sex-linked recessive
Sex-linked recessive conditions are much more common in males because they only have one X chromosome, meaning a single copy of the mutated gene is enough to cause the disease.
autosomal dominant
Autosomal dominant conditions affect males and females at equal rates, which contradicts the fact that this condition is more common in males.
autosomal recessive
Autosomal recessive conditions affect males and females at equal rates, which contradicts the fact that this condition is more common in males.
When a red camellia flower is crossed with a white camellia flower, all the offspring are covered in both red and white petals.
What is the reason for this occurrence?
One gene is controlling multiple characteristics.
Environmental factors affect the phenotype of camellia flowers.
Alleles for both red and white colour in camellia flowers are recessive.
Petal colour in camellia flowers is controlled by a co-dominance pattern of inheritance.
Reveal Answer
One gene is controlling multiple characteristics.
This describes pleiotropy, where one gene affects multiple traits, rather than the expression of two different alleles for a single trait.
Environmental factors affect the phenotype of camellia flowers.
While the environment can influence some phenotypes, the simultaneous expression of both parental colors is a direct result of genetic inheritance, not environmental factors.
Alleles for both red and white colour in camellia flowers are recessive.
If both alleles were recessive, they would not both be visibly expressed in the offspring. Instead, both alleles are being expressed equally.
Petal colour in camellia flowers is controlled by a co-dominance pattern of inheritance.
Co-dominance occurs when both alleles in a heterozygote are fully expressed, resulting in offspring that display both parental traits simultaneously, such as red and white petals.